STRUCTURAL BASIS FOR ACTIVATION AND NON-CANONICAL CATALYSIS OF THE RAP GTPASE ACTIVATING PROTEIN DOMAIN OF PLEXIN

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

Plexins are cell surface receptors that bind semaphorins and transduce signals for Pool Skimmers regulating neuronal axon guidance and other processes.Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates the Ras homolog Rap through an ill-defined non-canonical catalytic mechanism.The p

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